Conclusion:
The tumor ablative potential of radiosurgery is more biologically potent compared with conventional radiotherapy, and thus, more likely to provide a durable retreatment success after conventional radiotherapy has failed. Because the radiosurgery dose volume is tightly conforming to the retreatment target volume, the potential for serious radiation induced tissue complications is reduced. Compared with traditional surgery for radiotherapy failure, radiosurgical treatment avoids a large operation, and thus avoids the potential wound healing problems and other complications associated with operating on tissues that have been devitalized by prior radiation therapy.

Due to its unique dose sculpting and tumor tracking capability, including Synchrony respiratory tracking, CyberKnife® radiosurgery spares more normal tissue from high dose reirradiation than any other radiosurgery system, over a much wider variety of body sites, making this device an ideal choice for retreatment of post-radiotherapy relapse lesions.