Rarely, melanomas arise in the retina (inside the eye). A number of institutions have reported local control rates in excess of 90% for melanoma lesions arising in the eye, using precision stereotactic radiotherapy or focal proton beam radiotherapy techniques(22,23,24). The small volume of these particular melanoma lesions allows very high-dose radiotherapy regimens to be used, which undoubtedly correlates with the reported high local control rates. The high radiotherapy doses have also produced significant ocular complications though, including glaucoma, retinal injury and optic nerve injury, highlighting the need for continued research to define the optimal radiation dose, volume and technique for these lesions (22,23,24).
Uveal Melanoma after radiation treatment
Written by Donald B. Fuller, M.D. – Radiation Oncologist