CyberKnife®

Gamma Knife®

Other Linac Systems (Elekta Synergy®, Novalis®, Varian Trilogy®, TomoTherapy®)

Radiosurgery Dedicated

Yes

Yes

No

 Anatomic Area treatable with
radiosurgical precision

Whole body

Brain/Skull base
(minus extreme lateral)

Varies

IMRT dosimetry Method

Yes

No

Yes

IGRT Set-up Visualization

Yes

No

Yes

Does “Conventional” Radiotherapy and/or IMRT

No

No

Yes

Rigid Brain or Body Frame  required for radiosurgical accuracy

No

Yes

Yes

Capable of conformally and
homogeneously treating a non-
spherical target volume > 3.5cm

Yes

No

Yes

Capable of fractionated
radiosurgery to better preserve
critical adjacent tissue

Yes

No

Yes

Tracks patient-induced motion with radiosurgical precision (<1mm)

Yes

N/A

Varies by method and manufacturer

Tracks spine motion with radiosurgical precision (<1mm)

Yes

N/A

No

Tracks organ induced target volume motion with radiosurgical precision (<1mm)

Yes

N/A

No

Tracks respiration induced organ motion with radiosurgical precision (<1.5mm)

Yes

N/A

No

Capable of real-time sub-millimeter translational and rotational beam adaptation to target volume motion

Yes

N/A

No